Optimizing Pharmaceutical Production Yields is a Challenge
Optimizing biopharmaceuticals production yield during fermentation processes – knowing how to control growth processes, when to add nutrients, change fermentation conditions and terminate the process – is extremely challenging.
Incorrect timing results in waste of resources and/or lower profits. Biomass concentration is the golden standard for tracking cells or microorganism growth and determining the optimal growth conditions.
Measuring biomass today (using techniques such as Optical Density or Live Counts) can take time, and is prone to errors. Moreover, since measurement is not performed continuously, biomass concentrations cannot be determined in real time and the precise point at which maximum yield is achieved is not known. Continuous measurement of CO2 concentrations is available today, but it is fairly inaccurate and may miss subtle yet important fluctuations in CO2 levels, which may be informative for decision making.